Effect of chronic kidney disease on serum resistin level.

BACKGROUND Chronic Kidney Diseases (CKD) of all etiologies are usually associated with Insulin Resistance (IR). Resistin is also a protein associated with IR. Some studies conducted abroad have shown that resistin level is higher among CKD patients. OBJECTIVE To test if serum resistin level is significantly higher in CKD patients compared to normal individuals. PATIENTS AND METHODS 96 CKD patients and 97 normal individuals were included in the study. Written informed consent was obtained from every individual. RESULTS Serum resistin level was higher in CKD patients compared to control subjects. The difference in serum resistin level between two groups was statistically significant. CONCLUSION Our study is probably the first study in India comparing serum resistin levels of CKD patients vis-à-vis control subjects. Further cellular research may be needed to explore this relation.